Hydrochloric Acid → HCID 57917691, compound

HRID 1878399Notes

Reaction equation

HRID 1878399 reaction equation
[C:1]([NH:5][C:6]([C:8]1[CH:9]=[C:10]([CH:14]([N:18]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)[CH:15]([CH3:17])[CH3:16])[CH:11]=[CH:12][CH:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl>O1CCOCC1>[C:1]([NH:5][C:6](=[O:7])[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]([N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[CH:15]([CH3:17])[CH3:16])[CH:9]=1)([CH3:3])([CH3:4])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57917643HCID 57917643, compound

Product 1

HCID 57917691HCID 57917691, compoundYield 0.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of tert-butyl 4-(1-(3-(tert-butylcarbamoyl)phenyl)-2-methylpropyl)piperazine-1-carboxylate (24 mg, 0,057 mmol) and 5M hydrochloric acid (0.20 mL) in 1,4-dioxane (2.0 mL) was stirred at 80° C. for 30 minutes. The reaction mixture was concentrated under vacuum and treated with strong cation exchange column chromatography to afford the title compound (13.6 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. additiontreated with strong cation exchange column chromatography

Sources & evidence

ORD record
ord-649d16d99fca4da893880a639f4b2728
Source dataset
uspto-grants-2012_11
Patent number
US08314091B2

Reaction notes

Loading…