Trifluoroacetic acid methylene chloride → HCID 86635135, compound

HRID 1878410Notes

Reaction equation

HRID 1878410 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:22]=[CH:23][CH:24]=1)[CH2:8][N:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1)=[O:4].ClCCl.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[N:9]1([CH2:8][C:7]2[CH:6]=[C:5]([CH:24]=[CH:23][CH:22]=2)[C:3]([O:2][CH3:1])=[O:4])[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 23023155HCID 23023155, compound

Product 1

HCID 86635135HCID 86635135, compound

Procedure

Tert-butyl 4-(3-(methoxycarbonyl)benzyl)piperazine-1-carboxylate (1.25 g, 3.74 mmol) was stirred with a 4/1 solution of dichloromethane/trifluoroacetic acid (20 mL) for 1 hour at room temperature. The solution was then concentrated under vacuum to afford the title compound (1.73 g). MS (ESI) m/z 235.1 [M+H]+

Workup

  1. concentrationThe solution was then concentrated under vacuum

Sources & evidence

ORD record
ord-e1c0b3c7bcd94f79a2acae3169fdbe0b
Source dataset
uspto-grants-2012_11
Patent number
US08314091B2

Reaction notes

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