Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | HCID 66878657 | HCID 66878657 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 66878540 | HCID 66878540 | 100.1% |
Reaction Steps
A suspension of tert-butyl piperazine-1-carboxylate (5.32 mmol, 0.990 g), (R)—N-sec-butyl-3-(chloromethyl)benzamide (5.32 mmol, 1.2 g), potassium carbonate (10.63 mmol, 1.469 g) and sodium iodide (0.532 mmol, 0.080 g) in acetonitrile (50 mL) were heated at 80° C. for 3 hours. The reaction mixture was diluted with ethyl acetate and water. The organic layer was separated, dried (magnesium sulfate) and concentrated under reduced pressure to give the title compound (2 g). MS (ESI) m/z 376.5 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08314091B2 |
|---|
| Source dataset | uspto-grants-2012_11 |
|---|
| ORD ID | ord-93397fafad53434b85cb177b9145dc77 |
|---|
| Source note | uspto-grants-2012_11 |
|---|
