反应详情

温度

80 °C

A suspension of tert-butyl piperazine-1-carboxylate (5.32 mmol, 0.990 g), (R)—N-sec-butyl-3-(chloromethyl)benzamide (5.32 mmol, 1.2 g), potassium carbonate (10.63 mmol, 1.469 g) and sodium iodide (0.532 mmol, 0.080 g) in acetonitrile (50 mL) were heated at 80° C. for 3 hours. The reaction mixture was diluted with ethyl acetate and water. The organic layer was separated, dried (magnesium sulfate) and concentrated under reduced pressure to give the title compound (2 g). MS (ESI) m/z 376.5 [M+H]+

1. customThe organic layer was separated
2. dry with materialdried (magnesium sulfate)
3. concentrationconcentrated under reduced pressure