反应详情

A solution of 300 mg of 6-(6-benzyloxypyrid-2-yl)-N-phenylimidazo[1,2-a]pyridine-2-carboxamide in 3 mL of trifluoroacetic acid is stirred at 25° C. for 48 hours and then evaporated to dryness under reduced pressure at 45° C. The residue is triturated with ether, filtered off and dried, and then triturated again with 2 mL of saturated sodium bicarbonate solution, washed twice with 2 mL of water and twice with 2 mL of ethyl ether and dried under reduced pressure to give 168 mg of 6-(6-hydroxypyrid-2-yl)-N-phenylimidazo[1,2-a]pyridine-2-carboxamide in the form of a beige-coloured solid.

1. customevaporated to dryness under reduced pressure at 45° C
2. customThe residue is triturated with ether
3. filtrationfiltered off
4. customdried
5. customtriturated again with 2 mL of saturated sodium bicarbonate solution
6. washwashed twice with 2 mL of water and twice with 2 mL of ethyl ether
7. customdried under reduced pressure