反应详情

There was dissolved, in methylene chloride (2 mL), 5-chloro-7-morpholin-4-yl-pyrazolo[1,5-a]pyrimidine (100 mg, 0.419 mM), then N-bromo-succinimide (78.8 mg, 0.443 mM) was added to the solution and the mixture was stirred at room temperature for one hour. This reaction liquid was diluted with a saturated aqueous sodium bicarbonate solution and then extracted with ethyl acetate. The extracts thus obtained were combined, dried over anhydrous sodium sulfate and the solvent was then distilled off. The resulting residue was purified by the silica gel column chromatography (methylene chloride) to thus give the title compound (80.7 mg, yield: 61%).

1. customThis reaction liquid
2. extractionextracted with ethyl acetate
3. customThe extracts thus obtained
4. dry with materialdried over anhydrous sodium sulfate
5. distillationthe solvent was then distilled off
6. customThe resulting residue was purified by the silica gel column chromatography (methylene chloride)