Morpholine → HCID 58531012, compound

HRID 1878537Notes

Reaction equation

HRID 1878537 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:18]=[C:11]3[N:12]=[C:13]([Cl:17])[CH:14]=[C:15](Cl)[N:10]3[N:9]=2)=[CH:4][CH:3]=1.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>O1CCOCC1.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:18]=[C:11]3[N:12]=[C:13]([Cl:17])[CH:14]=[C:15]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:10]3[N:9]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 8083MorpholineHCID 49761377HCID 49761377, compound

Product 1

HCID 58531012HCID 58531012, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

There was dissolved, in 1,4-dioxane (5 mL), 2-(4-bromo-phenyl)-5,7-dichloro-pyrazolo[1,5-a]pyrimidine (217 mg, 0.633 mM), then morpholine (110 μL, 1.27 mM) was added to the solution and the mixture was stirred at room temperature for one hour. The solvent was distilled off from this reaction mixture and the residue thus obtained was diluted with water and then extracted with methylene chloride. The extracts obtained were combined together, dried over anhydrous sodium sulfate, the solvent was distilled off and then the resulting solid was washed with methanol to thus give the title compound (240 mg, yield: 96%).

Workup

  1. distillationThe solvent was distilled off from this reaction mixture
  2. customthe residue thus obtained
  3. extractionextracted with methylene chloride
  4. customThe extracts obtained
  5. dry with materialdried over anhydrous sodium sulfate
  6. distillationthe solvent was distilled off
  7. washthe resulting solid was washed with methanol

Sources & evidence

ORD record
ord-291bddb2bc6b4b9f91af80e1bcf4985c
Source dataset
uspto-grants-2012_11
Patent number
US08314098B2

Reaction notes

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