Acetic Acid → HCID 70999603, compound

HRID 1878563Notes

Reaction equation

HRID 1878563 reaction equation
[N:1]1([C:7]2[N:12]3[N:13]=[C:14]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH:15]=[C:11]3[N:10]=[C:9]([NH:22][NH2:23])[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:24][C:25]1[O:26][C:27]2[C:33]([CH:34]=O)=[CH:32][CH:31]=[CH:30][C:28]=2[CH:29]=1.C(O)(=O)C>C(O)C>[CH3:24][C:25]1[O:26][C:27]2[C:33]([CH:34]=[N:23][NH:22][C:9]3[CH:8]=[C:7]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)[N:12]4[N:13]=[C:14]([C:16]5[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=5)[CH:15]=[C:11]4[N:10]=3)=[CH:32][CH:31]=[CH:30][C:28]=2[CH:29]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 132018992-Methyl-7-benzofurancarboxaldehydeHCID 70867226HCID 70867226, compound

Product 1

HCID 70999603HCID 70999603, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl-hydrazine (25 mg, 0.081 mM) in absolute ethanol (2.0 mL), there were added 2-methyl-7-formyl-benzofuran (19 mg, 0.12 mM) and acetic acid (2.0 μL) and the mixture was stirred at room temperature for 3 hours. The precipitated solid was recovered through filtration and washed with ethanol to thus give the title compound (28 mg, yield: 78%).

Workup

  1. filtrationThe precipitated solid was recovered through filtration
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-e1144ab26cd544adaa9b32b55ed6756b
Source dataset
uspto-grants-2012_11
Patent number
US08314098B2

Reaction notes

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