Acetic Acid → HCID 77967092, compound

HRID 1878565Notes

Reaction equation

HRID 1878565 reaction equation
[N:1]1([C:7]2[N:12]3[N:13]=[C:14]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH:15]=[C:11]3[N:10]=[C:9]([NH:22][NH2:23])[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH:24]([C:26]1[CH:34]=[CH:33][CH:32]=[C:31]2[C:27]=1[CH:28]=[CH:29][NH:30]2)=O.C(O)(=O)C>C(O)C>[NH:30]1[C:31]2[C:27](=[C:26]([CH:24]=[N:23][NH:22][C:9]3[CH:8]=[C:7]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)[N:12]4[N:13]=[C:14]([C:16]5[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=5)[CH:15]=[C:11]4[N:10]=3)[CH:34]=[CH:33][CH:32]=2)[CH:28]=[CH:29]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 333703Indole-4-carboxaldehydeHCID 70867226HCID 70867226, compound

Product 1

HCID 77967092HCID 77967092, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl-hydrazine (15 mg, 0.048 mM) in absolute ethanol (2.0 mL), there were added 4-formyl-indole (11 mg, 0.076 mM) and acetic acid (2.0 μL) and the mixture was stirred at room temperature for 3 hours. The precipitated solid was filtered off and then washed with ethanol to thus give the title compound (12 mg, yield: 58%).

Workup

  1. filtrationThe precipitated solid was filtered off
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-1915d7d9b07542ada6d4f8d06de0a891
Source dataset
uspto-grants-2012_11
Patent number
US08314098B2

Reaction notes

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