HCID 70867226, compound → HCID 70999531, compound

HRID 1878566Notes

Reaction equation

HRID 1878566 reaction equation
[N:1]1([C:7]2[N:12]3[N:13]=[C:14]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH:15]=[C:11]3[N:10]=[C:9]([NH:22][NH2:23])[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH3:24][O:25][C:26]1[S:27][C:28]2[C:29](=[C:31]([CH:35]=O)[CH:32]=[CH:33][CH:34]=2)[N:30]=1>C(O)C>[CH3:24][O:25][C:26]1[S:27][C:28]2[CH:34]=[CH:33][CH:32]=[C:31]([CH:35]=[N:23][NH:22][C:9]3[CH:8]=[C:7]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)[N:12]4[N:13]=[C:14]([C:16]5[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=5)[CH:15]=[C:11]4[N:10]=3)[C:29]=2[N:30]=1

Participants

4

Reactant 2

HCID 70867226HCID 70867226, compoundHCID 86659724HCID 86659724, compound

Product 1

HCID 70999531HCID 70999531, compoundYield 85.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

There was dissolved, in ethanol (2 mL), (7-morpholin-4-yl-2-phenyl-pyrazolo-[1,5-a]pyrimidin-5-yl)-hydrazine (15.1 mg, 0.0487 mM) and then 2-methoxy-benzo-thiazole-4-carbaldehyde (10.4 mg, 0.054 mM) was added to the solution and the mixture was stirred at room temperature for one hour. This reaction liquid was filtered and then the resulting solid was washed with diethyl ether to thus give the title compound (20.1 mg, yield: 85%).

Workup

  1. customThis reaction liquid
  2. filtrationwas filtered
  3. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-df873cf7cab2492d9e4c597c26ac7d5f
Source dataset
uspto-grants-2012_11
Patent number
US08314098B2

Reaction notes

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