3-acetylbenzaldehyde → HCID 70999655, compound

HRID 1878587Notes

Reaction equation

HRID 1878587 reaction equation
[N:1]1([C:7]2[N:12]3[N:13]=[C:14]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=4)[CH:15]=[C:11]3[N:10]=[C:9]([NH:22][NH2:23])[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=O)(=[O:26])[CH3:25]>C(O)C>[C:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=[N:23][NH:22][C:9]1[CH:8]=[C:7]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[N:12]2[N:13]=[C:14]([C:16]3[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=3)[CH:15]=[C:11]2[N:10]=1)(=[O:26])[CH3:25]

Participants

4

Reactant 2

HCID 6434363-acetylbenzaldehydeHCID 70867116HCID 70867116, compound

Product 1

HCID 70999655HCID 70999655, compoundYield 77.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

There was dissolved, in ethanol (2 mL), (7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (30.6 mg, 0.0983 mM), then 3-acetyl-benzaldehyde (14.6 mg, 0.0983 mM) was added to the solution and the mixture was stirred at room temperature overnight. The reaction liquid was filtered and then the resulting solid was washed with diethyl ether to thus give the title compound (33.6 mg, yield: 77%).

Workup

  1. customThe reaction liquid
  2. filtrationwas filtered
  3. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-dfb777223e874aff920bdea5ebf58b86
Source dataset
uspto-grants-2012_11
Patent number
US08314098B2

Reaction notes

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