3-(Prop-1-en-2-yl)benzaldehyde → HCID 86659734, compound

HRID 1878588Notes

Reaction equation

HRID 1878588 reaction equation
[N:1]1([C:7]2[N:12]3[N:13]=[C:14]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=4)[CH:15]=[C:11]3[N:10]=[C:9]([NH:22][NH2:23])[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=O)([CH3:26])=[CH2:25]>C(O)C>[C:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=[N:23][NH:22][C:9]1[CH:8]=[C:7]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[N:12]2[N:13]=[C:14]([C:16]3[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=3)[CH:15]=[C:11]2[N:10]=1)([CH3:26])=[CH2:25]

Participants

4

Reactant 2

HCID 197448413-(Prop-1-en-2-yl)benzaldehydeHCID 70867116HCID 70867116, compound

Product 1

HCID 86659734HCID 86659734, compoundYield 62%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

There was dissolved, in ethanol (2 mL), (7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (30.4 mg, 0.0976 mM), then 3-isopropenyl-benzaldehyde (14.3 mg, 0.0976 mM) was added to the solution and the mixture was stirred at room temperature overnight. The reaction liquid was filtered and then the resulting solid was washed with diethyl ether to thus give the title compound (26.6 mg, yield: 62%).

Workup

  1. customThe reaction liquid
  2. filtrationwas filtered
  3. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-97f3f827e1224f379efb69dce181795c
Source dataset
uspto-grants-2012_11
Patent number
US08314098B2

Reaction notes

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