4-Pyridin-3-yl-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine → 2-(6-Methyl-pyridin-2-yl)-4-pyridin-3-yl-7H-pyrrolo[2,3-d]pyrimidine

HRID 1878591Notes

Reaction equation

HRID 1878591 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[C:8]3[CH:21]=[CH:20][NH:19][C:9]=3[N:10]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=3)[N:12]=2)[CH:2]=1.Cl[C:23]1C2C=CNC=2N=C(C2C=CC=CN=2)N=1.ClC1C2C=CNC=2N=C(C2C=CC=C(C)N=2)N=1>>[CH3:23][C:15]1[N:14]=[C:13]([C:11]2[N:12]=[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)[C:8]3[CH:21]=[CH:20][NH:19][C:9]=3[N:10]=2)[CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 687388684-Pyridin-3-yl-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidineHCID 866324274-Chloro-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidineHCID 866324284-chloro-2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine2×

Product 1

HCID 689353862-(6-Methyl-pyridin-2-yl)-4-pyridin-3-yl-7H-pyrrolo[2,3-d]pyrimidine

Procedure

2-(6-Methyl-pyridin-2-yl)-4-pyridin-3-yl-7H-pyrrolo[2,3-d]pyrimidine is prepared by an analogous method to 4-pyridin-3-yl-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine (Example 1) by replacing 4-chloro-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine (Intermediate 1) with 4-chloro-2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine (Intermediate 2).

Sources & evidence

ORD record
ord-5b8ea4d36a8a4dad924401310a934bce
Source dataset
uspto-grants-2012_11
Patent number
US08314112B2

Reaction notes

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