4-chloro-6-(6-methyl-pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine → 6-(6-Methyl-pyridin-2-yl)-4-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine

HRID 1878592Notes

Reaction equation

HRID 1878592 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2N=[C:10]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[C:11]3[CH:16]=[CH:15][NH:14][C:12]=3[N:13]=2)[CH:5]=[CH:4][CH:3]=1.Cl[C:24]1C2C=CNC=2N=C(C2C=CC=CN=2)N=1.ClC1C=C(C2C=CC=C(C)N=2)N=C2NC=CC=12>>[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[N:13]=[C:12]3[NH:14][CH:15]=[CH:16][C:11]3=[C:10]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[CH:24]=2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 687902414-chloro-6-(6-methyl-pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine2×HCID 689353862-(6-Methyl-pyridin-2-yl)-4-pyridin-3-yl-7H-pyrrolo[2,3-d]pyrimidineHCID 866324274-Chloro-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 689404316-(6-Methyl-pyridin-2-yl)-4-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine

Procedure

6-(6-Methyl-pyridin-2-yl)-4-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine is prepared by an analogous method to that for 2-(6-methyl-pyridin-2-yl)-4-pyridin-3-yl-7H-pyrrolo[2,3-d]pyrimidine (Example 2) by replacing 4-chloro-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine (Intermediate 1) with 4-chloro-6-(6-methyl-pyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine (Intermediate 6).

Sources & evidence

ORD record
ord-c4541ef8d6d74cc79d2eeec8f280f6ea
Source dataset
uspto-grants-2012_11
Patent number
US08314112B2

Reaction notes

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