(4-methyl-piperazin-1-yl)-(4-{5-[2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyridin-3-yl}-phenyl)-methanone → (4-Methyl-piperazin-1-yl)-{4-[5-(2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyridin-3-yl]-phenyl}-methanone

HRID 1878596Notes

Reaction equation

HRID 1878596 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:17]=[N:18][CH:19]=[C:20]([C:22]4[C:23]5[CH:37]=[CH:36][NH:35][C:24]=5[N:25]=[C:26]([C:28]5[CH:33]=[CH:32][CH:31]=[C:30](C)[N:29]=5)[N:27]=4)[CH:21]=3)=[CH:12][CH:11]=2)=[O:9])[CH2:4][CH2:3]1.BrC1C=C(C2C3C=CNC=3N=C(C3C=CC=CN=3)N=2)C=NC=1>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:17]=[N:18][CH:19]=[C:20]([C:22]4[C:23]5[CH:37]=[CH:36][NH:35][C:24]=5[N:25]=[C:26]([C:28]5[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=5)[N:27]=4)[CH:21]=3)=[CH:14][CH:15]=2)=[O:9])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 44194349(4-methyl-piperazin-1-yl)-(4-{5-[2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyridin-3-yl}-phenyl)-methanoneHCID 687601424-(5-Bromo-pyridin-3-yl)-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 68934781(4-Methyl-piperazin-1-yl)-{4-[5-(2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyridin-3-yl]-phenyl}-methanone

Procedure

(4-Methyl-piperazin-1-yl)-{4-[5-(2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyridin-3-yl]-phenyl}-methanone is prepared by an analogous method to that for (4-methyl-piperazin-1-yl)-(4-{5-[2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyridin-3-yl}-phenyl)-methanone (Example 9) by replacing 4-(5-bromo-pyridin-3-yl)-2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine (Example 16) with 4-(5-bromo-pyridin-3-yl)-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine (Example 44).

Sources & evidence

ORD record
ord-a6e15c8cb86e4fc8934d9627e61a7c6e
Source dataset
uspto-grants-2012_11
Patent number
US08314112B2

Reaction notes

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