(4-methyl-piperazin-1-yl)-(4-{5-[2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyridin-3-yl}-phenyl)-methanone → (4-Methyl-piperazin-1-yl)-{4-[5-(2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyridin-3-yl]-phenyl}-methanone

Participants

Role	Name	HCID	Charge
Reactant	(4-methyl-piperazin-1-yl)-(4-{5-[2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyridin-3-yl}-phenyl)-methanone	HCID 44194349	—
Reactant	4-(5-Bromo-pyridin-3-yl)-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine	HCID 68760142	—
Product	(4-Methyl-piperazin-1-yl)-{4-[5-(2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyridin-3-yl]-phenyl}-methanone	HCID 68934781	—

Reaction Steps

(4-Methyl-piperazin-1-yl)-{4-[5-(2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyridin-3-yl]-phenyl}-methanone is prepared by an analogous method to that for (4-methyl-piperazin-1-yl)-(4-{5-[2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-pyridin-3-yl}-phenyl)-methanone (Example 9) by replacing 4-(5-bromo-pyridin-3-yl)-2-(6-methyl-pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidine (Example 16) with 4-(5-bromo-pyridin-3-yl)-2-pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidine (Example 44).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08314112B2
Source dataset	uspto-grants-2012_11
ORD ID	ord-a6e15c8cb86e4fc8934d9627e61a7c6e
Source note	uspto-grants-2012_11