反应详情

温度

110 °C

2-Pyridin-2-yl-7H-pyrrolo[2,3-d]pyrimidin-4-ol (1 eq, 5.56 mmol, 1.18 g) is added to POCl3 (10 ml), and the resulting mixture is heated at 110° C. for 18 h. The mixture is concentrated in vacuo and then water is added. The aqueous solution is heated at 40° C. for 15 min, cooled down to r.t., and adjusted to pH 9 with aqueous NaOH solution (8 M). The resulting precipitate is filtered and washed with water and MeOH to give the title compound; [M+H]+=231.

1. concentrationThe mixture is concentrated in vacuo
2. additionwater is added
3. temperatureThe aqueous solution is heated at 40° C. for 15 min
4. temperaturecooled down to r.t.
5. filtrationThe resulting precipitate is filtered
6. washwashed with water and MeOH