反应详情

温度

23 °C

To a solution of methyl 1-(1-(tert-butyldimethylsilyloxy)-2-methylpropan-2-yl)-6-oxo-1,6-dihydropyridine-3-carboxylate (3600 mg, 10.6 mmol) in THF (10 mL) and MeOH (5 mL) was added NaOH (3181 μl, 31.8 mmol). The solution was stirred at 23° C. for 48 h and was partitioned between CH2Cl2 and 10% citric acid (aq. pH˜4). The aqueous was extracted with CH2Cl2 (3×50 mL). The combined organics were dried with brine and MgSO4, and concentrated to a yellow solid under reduced pressure. MS (ESI pos. ion) m/z (MH+): 326. Calc'd exact mass for C16H27NO4Si: 325.

1. customwas partitioned between CH2Cl2 and 10% citric acid (aq. pH˜4)
2. extractionThe aqueous was extracted with CH2Cl2 (3×50 mL)
3. dry with materialThe combined organics were dried with brine and MgSO4
4. concentrationconcentrated to a yellow solid under reduced pressure