Hydrochloric Acid → HCID 59843081, compound

HRID 1878789Notes

Reaction equation

HRID 1878789 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11](=[O:14])[N:10]([CH2:15][CH2:16][O:17][C:18]3[C:27]4[C:22](=[CH:23][C:24]([O:28][CH3:29])=[CH:25][CH:26]=4)[N:21]=[CH:20][CH:19]=3)[N:9]=2)[CH:5]=[CH:4][C:3]=1[C@H:30]([NH:35][S@@](C(C)(C)C)=O)[C:31]([F:34])([F:33])[F:32].Cl>CO>[NH2:35][C@@H:30]([C:3]1[CH:4]=[CH:5][C:6]([C:8]2[CH:13]=[CH:12][C:11](=[O:14])[N:10]([CH2:15][CH2:16][O:17][C:18]3[C:27]4[C:22](=[CH:23][C:24]([O:28][CH3:29])=[CH:25][CH:26]=4)[N:21]=[CH:20][CH:19]=3)[N:9]=2)=[CH:7][C:2]=1[Cl:1])[C:31]([F:33])([F:32])[F:34]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68810783HCID 68810783, compound

Product 1

HCID 59843081HCID 59843081, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of (R)—N—((S)-1-(2-chloro-4-(1-(2-(7-methoxyquinolin-4-yloxy)ethyl)-6-oxo-1,6-dihydropyridazin-3-yl)phenyl)-2,2,2-trifluoroethyl)-2-methylpropane-2-sulfinamide (170 mg, 279 μmol) in MeOH (4 mL) was stirred with 5 N HCl (4 mL) at 23° C. for 18 hours. The solvents were then largely removed under reduced pressure and residue partitioned between 9:1 CHCl3/IPA (20 mL) and aqueous pH adjusted to 14 with NaOH (5 M, 4 mL). The aqueous layer was further extracted with 9:1 CHCl3/IPA (2×10 mL). The combined organics were then dried over MgSO4, concentrated, and purified on silica (12 g) eluting with 0>5% NH3 in MeOH (2 M)/DCM. Product was isolated as a white fluffy solid from lyophilized 50% ACN/water. MS (ESI pos. ion) m/z: 506 (MH+); calc'd for C24H20ClF3N4O3: 505. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.93 (s, 3 H) 4.74 (t, J=4.27 Hz, 2 H) 4.92 (t, J=4.52 Hz, 2 H) 5.18 (q, J=7.36 Hz, 1 H) 7.14 (d, J=10.04 Hz, 1 H) 7.21-7.28 (m, 1 H) 7.40 (d, J=6.53 Hz, 1 H) 7.49 (s, 1 H) 7.87-7.96 (m, 3 H) 8.05 (d, J=9.03 Hz, 1 H) 8.14 (d, J=10.04 Hz, 1 H) 8.97 (d, J=6.02 Hz, 1 H). 13C NMR (101 MHz, DMSO-d6) δ ppm 48.21, 54.49, 66.32, 99.81, 113.27, 118.38, 122.46, 123.30, 124.68, 128.27, 128.39, 129.30, 132.34, 134.84, 140.24, 145.85, 157.66, 161.35 19F NMR (376 MHz, DMSO-d6) δ ppm −73.63 (s, 3 F).

Workup

  1. customThe solvents were then largely removed under reduced pressure and residue
  2. custompartitioned between 9:1 CHCl3/IPA (20 mL) and aqueous pH
  3. extractionThe aqueous layer was further extracted with 9:1 CHCl3/IPA (2×10 mL)
  4. dry with materialThe combined organics were then dried over MgSO4
  5. concentrationconcentrated
  6. custompurified on silica (12 g)
  7. washeluting with 0>5% NH3 in MeOH (2 M)/DCM
  8. customProduct was isolated as a white fluffy solid from lyophilized 50% ACN/water

Sources & evidence

ORD record
ord-8f663afd48c64e97ad66a7bfefdc9c88
Source dataset
uspto-grants-2012_11
Patent number
US08314087B2

Reaction notes

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