Hydrazine hydrate (1:1) → HCID 136403433, compound

HRID 1878939Notes

Reaction equation

HRID 1878939 reaction equation
O.[NH2:2][NH2:3].[Cl:4][C:5]1[C:6]([OH:23])=[CH:7][C:8]([OH:22])=[C:9]([C:11](=O)[CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[CH:10]=1>C(O)C>[Cl:4][C:5]1[C:6]([OH:23])=[CH:7][C:8]([OH:22])=[C:9]([C:11](=[N:2][NH2:3])[CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[CH:10]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 11277788HCID 11277788, compound

Product 1

HCID 136403433HCID 136403433, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine hydrate (0.166 ml, 3.42 mmol) is added to a solution of 1-(5-chloro-2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone (1a) (0.5 g, 1.71 mmol) in 95% ethanol (5 ml). The mixture is heated under reflux for 7 hours. Solvent is concentrated in vacuo, the residue treated with water, filtered of and recrystallyzed from 2-propanol.

Workup

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 7 hours
  3. concentrationSolvent is concentrated in vacuo
  4. additionthe residue treated with water
  5. filtrationfiltered of and

Sources & evidence

ORD record
ord-a7ebba5ab7cf44b1a423fb6d2b6dfa57
Source dataset
uspto-grants-2012_11
Patent number
US08314132B2

Reaction notes

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