Allyl bromide → HCID 11681182, compound

HRID 1878965Notes

Reaction equation

HRID 1878965 reaction equation
[CH3:1][S:2]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[C:7]=1[F:18])(=[O:4])=[O:3].C(=O)([O-])[O-].[K+].[K+].[CH2:25](Br)[CH:26]=[CH2:27]>C(#N)C>[CH3:1][S:2]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:12]2[CH2:13][CH2:14][N:15]([CH2:27][CH:26]=[CH2:25])[CH2:16][CH2:17]2)[C:7]=1[F:18])(=[O:3])=[O:4]

Participants

5

Reactant 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 57448046HCID 57448046, compound

Product 1

HCID 11681182HCID 11681182, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 1: 2-fluoro-3-piperidin-4-ylphenyl methanesulfonate (0.01 g), acetonitrile (2 ml), potassium carbonate (0.01 g) and allylbromide (0.01 g). MS m/z (rel. intensity, 70 eV) 313 (M+, 28), 312 (25), 286 (42), 234 (bp), 207 (19).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-8683ec43b7524aafa28cf7161d80f65e
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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