Potassium Carbonate → HCID 86085871, compound

HRID 1878982Notes

Reaction equation

HRID 1878982 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[C:8]=2[OH:17])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:25][CH2:26][F:27]>C(#N)C>[F:27][CH2:26][CH2:25][N:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:15])([F:16])[F:14])[C:8]=2[OH:17])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 129822-Fluoroethyl bromideHCID 57448052HCID 57448052, compound

Product 1

HCID 86085871HCID 86085871, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 1: 2-piperidin-4-yl-6-(trifluoromethyl)phenol (0.01 g, 0.04 mmol), acetonitrile (2 ml), potassium carbonate (0.01 g) and 1-bromo-2-fluoroethane (0.01 ml). MS m/z (relative intensity, 70 eV) 291 (M+, 29), 259 (15), 258 (bp), 194 (22), 167 (11).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-33de305921cb4620b03ccd1c373532bb
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

Loading…