1-Bromo-2-methylpropane → HCID 67533716, compound

HRID 1878984Notes

Reaction equation

HRID 1878984 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[C:8]=2[OH:17])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[CH2:24](Br)[CH:25]([CH3:27])[CH3:26]>C(#N)C>[CH2:24]([N:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:15])([F:16])[F:14])[C:8]=2[OH:17])[CH2:3][CH2:2]1)[CH:25]([CH3:27])[CH3:26]

Participants

5

Reactant 3

HCID 65551-Bromo-2-methylpropaneHCID 11430Potassium CarbonateHCID 57448052HCID 57448052, compound

Product 1

HCID 67533716HCID 67533716, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 1: 2-piperidin-4-yl-6-(trifluoromethyl)phenol (0.01 g, 0.04 mmol), acetonitrile (2 ml), potassium carbonate (0.01 g) and isobutyl bromide (0.01 ml). MS m/z (relative intensity, 70 eV) 301 (M+, 4), 259 (13), 258 (bp), 238 (9), 194 (11).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-dd088c5de41c49868332677d6a7fd9f8
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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