Potassium Carbonate → HCID 86085872, compound

HRID 1878985Notes

Reaction equation

HRID 1878985 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[C:8]=2[OH:17])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[F:24][C:25]([F:30])([F:29])[CH2:26]CI>C(#N)C>[F:24][C:25]([F:30])([F:29])[CH2:26][N:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:15])([F:16])[F:14])[C:8]=2[OH:17])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1561651,1,1-Trifluoro-3-iodopropaneHCID 57448052HCID 57448052, compound

Product 1

HCID 86085872HCID 86085872, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 1: 2-piperidin-4-yl-6-(trifluoromethyl)phenol (0.01 g, 0.04 mmol), acetonitrile (2 ml), potassium carbonate (0.01 g) and 1,1,1-trifluoro-3-iodopropane (0.01 ml). MS m/z (relative intensity, 70 eV) 341 (M+, 40), 258 (bp), 195 (25), 167 (28), 152 (56).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-555a042cf4644e9687d6f1511063c233
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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