Allyl bromide → 1-[3-(1-Allylpiperidin-4-YL)-2-fluorophenyl]-2,2,2-trifluoroethanone

HRID 1879001Notes

Reaction equation

HRID 1879001 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[C:6]=1[F:17])=[O:4].C(=O)([O-])[O-].[K+].[K+].[CH2:26](Br)[CH:27]=[CH2:28]>C(#N)C>[CH2:28]([N:14]1[CH2:15][CH2:16][CH:11]([C:7]2[C:6]([F:17])=[C:5]([C:3](=[O:4])[C:2]([F:1])([F:18])[F:19])[CH:10]=[CH:9][CH:8]=2)[CH2:12][CH2:13]1)[CH:27]=[CH2:26]

Participants

5

Reactant 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 67532664HCID 67532664, compound

Product 1

HCID 675331771-[3-(1-Allylpiperidin-4-YL)-2-fluorophenyl]-2,2,2-trifluoroethanone

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Preparation according to Example 1: 2,2,2-trifluoro-1-(2-fluoro-3-piperidin-4-ylphenyl)ethanone (0.01 g), acetonitrile (2 ml), potassium carbonate (0.01 g) and allylbromide (0.01 g). MS m/z (rel. intensity, 70 eV) 315 (M+, 60), 314 (82), 288 (bp), 286 (31), 96 (36).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-a24748bf138f4d7fb7d399d3e9a04d0c
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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