Hydrochloric Acid → HCID 11702233, compound

HRID 1879032Notes

Reaction equation

HRID 1879032 reaction equation
[F:1][C:2]1[C:7]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:6][CH:5]=[CH:4][C:3]=1[C:13]1[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][CH3:21])[CH2:17][CH:18]=1.Cl>[Pd]>[F:1][C:2]1[C:7]([O:8][C:9]([F:10])([F:11])[F:12])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:13]1[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][CH3:21])[CH2:17][CH2:18]1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 57453799HCID 57453799, compound

Product 1

HCID 11702233HCID 11702233, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Preparation according to preparation 18: 4-[2-fluoro-3-(trifluoromethoxy)phenyl]-1-propyl-1,2,3,6-tetrahydro-pyridine (0.55 g, 1.8 mmol), palladium on carbon (0.09 g) and hydrochloric acid (0.5 ml, cone). Yield: 0.22 g (40%). The amine was converted to the hydrochloric acid salt and recrystallized from ethanol/diethyl ether: M.p. 221-222° C. MS m/z (relative intensity, 70 eV) 305 (M+, 3), 277 (14), 276 (bp), 233 (6) 193 (8).

Workup

  1. customPreparation
  2. customaccording to preparation 18
  3. customrecrystallized from ethanol/diethyl ether

Sources & evidence

ORD record
ord-6aef542bbf764c838f337fd7cfe82f13
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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