HCID 57448070, compound → 4-{2-Fluoro-3-[(trifluoromethyl)sulfonyl]phenyl}piperidine

HRID 1879037Notes

Reaction equation

HRID 1879037 reaction equation
[F:1][C:2]1[C:7]([S:8]([C:11]([F:14])([F:13])[F:12])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:15]1[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=1>[Pt]=O.CO>[F:1][C:2]1[C:7]([S:8]([C:11]([F:14])([F:13])[F:12])(=[O:9])=[O:10])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1

Participants

4

Reactant 1

HCID 57448070HCID 57448070, compound

Product 1

HCID 574480514-{2-Fluoro-3-[(trifluoromethyl)sulfonyl]phenyl}piperidine

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

Preparation according to preparation 9: 4-{2-fluoro-3-[(trifluoromethyl)sulfonyl]phenyl}-pyridine (0.16 g, 0.53 mmol), methanol (10 ml), platinum oxide (0.02 g). Yield: 0.11 g. MS m/z (relative intensity, 70 eV) 311 (M+, 2), 291 (47), 164 (92), 130 (62) 69 (bp).

Workup

  1. customPreparation
  2. customaccording to preparation 9

Sources & evidence

ORD record
ord-f6cdfbfdf1ec45fbb65cc0864d64d440
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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