Methyl 4-[2-fluoro-3-(methylsulfonyl)phenyl]piperazine-1-carboxylate → 1-[2-Fluoro-3-(methylsulfonyl)phenyl]piperazine

HRID 1879056Notes

Reaction equation

HRID 1879056 reaction equation
[F:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][N:15](C(OC)=O)[CH2:14][CH2:13]1>C(O)C.Cl>[F:1][C:2]1[C:7]([S:8]([CH3:11])(=[O:9])=[O:10])=[CH:6][CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1

Participants

4

Reactant 1

HCID 57448075Methyl 4-[2-fluoro-3-(methylsulfonyl)phenyl]piperazine-1-carboxylate

Product 1

HCID 574480501-[2-Fluoro-3-(methylsulfonyl)phenyl]piperazine

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

Preparation according to preparation 29: methyl 4-[2-fluoro-3-(methylsulfonyl)phenyl]piperazine-1-carboxylate (1.0 g, 3.16 mmol) in ethanol (8 ml), hydrochloric acid (6 M, 20 ml). Yield: 0.34 g. MS m/z (rel. intensity, 70 eV) 258 (M+, 17), 215 (13), 216 (bp), 209 (6), 137 (9).

Workup

  1. customPreparation
  2. customaccording to preparation 29

Sources & evidence

ORD record
ord-2c04d8662bf643299e869a8a5025b29f
Source dataset
uspto-grants-2012_11
Patent number
US08314126B2

Reaction notes

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