Water → 3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester 4-thiocarbamoyl benzoate

HRID 1879077Notes

Reaction equation

HRID 1879077 reaction equation
[C:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].[CH3:13][CH2:14][C:15]([N:38]([CH3:40])[CH3:39])([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[CH2:16][O:17][C:18]([C:20]1[CH:21]=[C:22]([O:30][CH3:31])[C:23]([O:28][CH3:29])=[C:24]([O:26][CH3:27])[CH:25]=1)=[O:19].O>C(O)C>[C:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].[CH3:40][N:38]([CH3:39])[C:15]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)([CH2:14][CH3:13])[CH2:16][O:17][C:18](=[O:19])[C:20]1[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH3:29])=[C:22]([O:30][CH3:31])[CH:21]=1

Participants

5

Reactant 3

HCID 962WaterHCID 5573TrimebutineHCID 167725014-Carbamothioylbenzoic acid

Product 1

HCID 866165533,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester 4-thiocarbamoyl benzoate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 4-(thiocarbamoyl)benzoic acid (0.1 mol) and trimebutine (0.1 mol), water (200 mL) and ethyl alcohol (20 mL) have been added and the resulting suspension has been stirred at room temperature until clear. Then the solution has been frozen and lyophilized furnishing the desired salt (quantitative yield).

Workup

  1. additionhave been added
  2. temperatureThen the solution has been frozen

Sources & evidence

ORD record
ord-c2bbf2c77d9042dbbd82ebcbd4ba9a51
Source dataset
uspto-grants-2012_11
Patent number
US08314140B2

Reaction notes

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