反应详情

Ethyl phenylmethyl (2-fluoro-4-nitrophenyl)propanedioate (3.86 g, 10.6 mmol) dissolved in ethanol, was treated with ammonium formate (6.7 g, 10.6 mmol) and palladium on carbon 10% paste (380 mg) was added under argon. The reaction mixture was refluxed for 3 hours, cooled and filtered. Evaporated and purified by chromatography on silica gel eluting with ethyl acetate/hexane (1:1) to give the title compound as a yellow oil (1.26 g). LC/MS: Rt=2.10, [MH]+ 198.

1. additionwas added under argon
2. temperatureThe reaction mixture was refluxed for 3 hours
3. temperaturecooled
4. filtrationfiltered
5. customEvaporated
6. custompurified by chromatography on silica gel eluting with ethyl acetate/hexane (1:1)