HCID 68487772, compound → HCID 68492747, compound

HRID 1879170Notes

Reaction equation

HRID 1879170 reaction equation
C(OC(C1SC(C2C=NC=C(N(CCOC3C=CC(F)=CC=3)C)N=2)=NC=1C)=O)C.C([O:32][C:33]([C:35]1[S:39][C:38]([C:40]2[CH:45]=[N:44][CH:43]=[C:42]([N:46]([CH2:48][C:49]3[CH:54]=[CH:53][C:52]([F:55])=[CH:51][CH:50]=3)[CH3:47])[N:41]=2)=[N:37][C:36]=1[CH3:56])=[O:34])C>>[F:55][C:52]1[CH:53]=[CH:54][C:49]([CH2:48][N:46]([CH3:47])[C:42]2[N:41]=[C:40]([C:38]3[S:39][C:35]([C:33]([OH:34])=[O:32])=[C:36]([CH3:56])[N:37]=3)[CH:45]=[N:44][CH:43]=2)=[CH:50][CH:51]=1

Participants

3

Reactant 2

HCID 68487772HCID 68487772, compoundHCID 68488009HCID 68488009, compound

Product 1

HCID 68492747HCID 68492747, compoundYield 90%

Procedure

Part B. Following the procedure described in Example 25 (Part C), making variations as required to replace 2-(6-{[2-(4-fluoro-phenoxy)-ethyl]methyl-amino}-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid ethyl ester with 2-{6-[(4-fluoro-benzyl)-methyl-amino]-pyrazin-2-yl}-4-methyl-thiazole-5-carboxylic acid ethyl ester to give 2-{6-[(4-fluoro-benzyl)-methyl-amino]-pyrazin-2-yl}-4-methyl-thiazole-5-carboxylic acid in 90% yield.

Sources & evidence

ORD record
ord-0658e4a925404c52ab251737f6c559b9
Source dataset
uspto-grants-2012_11
Patent number
US08314138B2

Reaction notes

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