HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1879242Generated: October 25, 2026
Chlorosuccinimide → 2-Amino-5-Chloro-alpha-(Methoxyimino)-4-Thiazoleacetic Acid
https://huagongshe.com/reaction/1879242
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid | HCID 125216 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-Amino-5-Chloro-alpha-(Methoxyimino)-4-Thiazoleacetic Acid | HCID 54009366 | — |
Reaction Steps
To 500 mL of acetic acid were added 40.0 g (0.20 mol) of 2-amino-α-(methoxyimino)-4-thiazoleacetic acid (Aldrich Chemical Company, Milwaukee, Wis.) and 27.9 g (0.21 mol) N-chlorosuccinimide. The mixture was heated in a 70° C. bath. The solids dissolved within 30 minutes, and after 45 minutes the reaction was complete by MS. The dark solution was allowed to cool to room temperature and concentrated under vacuum to give a dark solid, which was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08314217B2 |
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| Source dataset | uspto-grants-2012_11 |
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| ORD ID | ord-fcfe42b1356c449ca4c12345e95d4b91 |
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| Source note | uspto-grants-2012_11 |
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