反应详情

温度

70 °C

To 500 mL of acetic acid were added 40.0 g (0.20 mol) of 2-amino-α-(methoxyimino)-4-thiazoleacetic acid (Aldrich Chemical Company, Milwaukee, Wis.) and 27.9 g (0.21 mol) N-chlorosuccinimide. The mixture was heated in a 70° C. bath. The solids dissolved within 30 minutes, and after 45 minutes the reaction was complete by MS. The dark solution was allowed to cool to room temperature and concentrated under vacuum to give a dark solid, which was used without purification.

1. dissolutionThe solids dissolved within 30 minutes
2. temperatureto cool to room temperature
3. concentrationconcentrated under vacuum
4. customto give a dark solid, which
5. customwas used without purification