HRID1879267
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 40 °C
PROCEDURE
实验过程
LiOH (3.0 eq.) was added to a 0.04M solution of methyl (9R,11S,14S,20E)-14-cyclohexyl-13-oxo-8-oxa-12,15-diazatetracyclo[20.3.1.12,6.19,12]octacosa-1(26),2(28),3,5,20,22,24-heptaene-11-carboxylate 110 in a mixture of THF:EtOH:H2O (2:1:1) and the reaction mixture was stirred at 40° C. for 2 h. The solvents were removed under reduced pressure, the residue was suspended in EtOAc/H2O, aqueous (1N) HCl was added to acidic pH and the phases separated. The collected organic layers were dried (Na2SO4) and evaporated under reduced pressure to afford a residue which was used without further purification. MS (ES+) m/z 517 (M+H)+
WORKUP
后处理
- customThe solvents were removed under reduced pressure
- additionaqueous (1N) HCl was added to acidic pH
- customthe phases separated
- dry with materialThe collected organic layers were dried (Na2SO4)
- customevaporated under reduced pressure
- customto afford a residue which
- customwas used without further purification