反应详情

To the organic phase of step 11 is added 1 equivalent aqueous hydrochloric acid and then the water removed by azeotropic distillation in vacuo. The precipitate is dissolved by addition of 2-propanol at 75° C. Concentration of the solution leads to crystallisation and the suspension is then cooled to RT. To ensure complete crystallisation, the suspension is aged at RT, then filtered and washed with a MIBK-2-propanol mixture. The product is dried in vacuo at 50° C.

1. customthe water removed by azeotropic distillation in vacuo
2. dissolutionThe precipitate is dissolved by addition of 2-propanol at 75° C
3. customConcentration of the solution leads to crystallisation
4. customcrystallisation
5. customis aged at RT
6. filtrationfiltered
7. washwashed with a MIBK-2-propanol mixture
8. customThe product is dried in vacuo at 50° C.