Triethylamine → 2,6-dichloro-N-[2-(4-chlorophenyl)-1-methylethyl]benzamide

HRID 1879436Notes

Reaction equation

HRID 1879436 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([NH2:12])[CH3:11])=[CH:5][CH:4]=1.C(N(CC)CC)C.[Cl:20][C:21]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:22]=1[C:23](Cl)=[O:24].[Cl-].[NH4+]>ClCCl>[Cl:20][C:21]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:22]=1[C:23]([NH:12][CH:10]([CH3:11])[CH2:9][C:6]1[CH:5]=[CH:4][C:3]([Cl:2])=[CH:8][CH:7]=1)=[O:24]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 25517Ammonium ChlorideHCID 783922,6-Dichlorobenzoyl chlorideHCID 107161p-Chloroamphetamine hydrochloride

Product 1

HCID 167467792,6-dichloro-N-[2-(4-chlorophenyl)-1-methylethyl]benzamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

100 mg of 1-(4-chlorophenyl)propan-2-amine hydrochloride (0.728 mmol) and 0.10 ml of triethylamine (0.728 mmol) are diluted in 3 ml of dichloromethane at room temperature, 152 mg of 2,6-dichlorobenzoyl chloride (0.728 mmol) are added to the reaction mixture. After 24 hours of stirring, 20 ml of DCM an 10 ml of saturated solution of ammonium chloride are added to the reaction mixture.

Sources & evidence

ORD record
ord-a92637e2e8434226bd16c98ec1e671a6
Source dataset
uspto-grants-2012_11
Patent number
US08314269B2

Reaction notes

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