反应详情

To tert-butyl 7-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-9H-carbazol-2-ylcarbamate (130 mg, 0.3 mmol) was added 10 mL of a 4 M HCl in dioxane solution. The mixture was stirred at rt for 5 h and concentrated under reduced pressure. The residue was washed with ether (15 mL) and suspended in EtOAc (50 mL). To this suspension was added 10 mL of a NaHCO3 (sat.) and the mixture was stirred for 5 min. The organic layer was dried over MgSO4 and concentrated to afford 7-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)-9H-carbazol-2-amine as a brown solid (95 mg, 95%). MS (ESI) m/z 333 (M+H+).

1. concentrationconcentrated under reduced pressure
2. washThe residue was washed with ether (15 mL)
3. additionTo this suspension was added 10 mL of a NaHCO3 (sat.)
4. stirringthe mixture was stirred for 5 min
5. dry with materialThe organic layer was dried over MgSO4
6. concentrationconcentrated