Phosphorus oxychloride → 4,5,5,5-Tetrafluoro-4-(trifluoromethyl)-1-pentene

HRID 1879609Notes

Reaction equation

HRID 1879609 reaction equation
O=P(Cl)(Cl)Cl.[F:6][C:7]([C:17]([F:20])([F:19])[F:18])([C:13]([F:16])([F:15])[F:14])[CH2:8][CH:9](I)[CH2:10]O>N1C=CC=CC=1>[F:6][C:7]([C:17]([F:18])([F:19])[F:20])([C:13]([F:14])([F:15])[F:16])[CH2:8][CH:9]=[CH2:10]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychloride2×HCID 27826014,5,5,5-Tetrafluoro-2-iodo-4-(trifluoromethyl)pentan-1-ol

Product 1

HCID 202612974,5,5,5-Tetrafluoro-4-(trifluoromethyl)-1-pentene

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Procedure

According to another embodiment, the reducing agent can include POCl3, pyridine and/or a mixture of POCl3 and pyridine. For example, the RF-intermediate 4,5,5,5-tetrafluoro-4-(trifluoromethyl)-2-iodopentan-1-ol can be reacted to form the RF-intermediate 4,5,5,5-tetrafluoro-4-(trifluoromethyl)pent-1-ene in the presence of a mixture of POCl3 and pyridine. This reaction can be performed while maintaining the temperature of the mixture between from about 0° C. to about 5° C., for example.

Sources & evidence

ORD record
ord-ffaabd0c09cb4c6aaa3b4d93bbb141ce
Source dataset
uspto-grants-2012_11
Patent number
US08318656B2

Reaction notes

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