3,3,3-Trifluoropropionic acid → 4-Nitrosotetrahydro-2H-pyran-4-yl 3,3,3-trifluoropropanoate

HRID 1879792Notes

Reaction equation

HRID 1879792 reaction equation
[O:1]1[CH2:6][CH2:5][C:4](=[N:7][OH:8])[CH2:3][CH2:2]1.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.[Pb+4].[F:26][C:27]([F:33])([F:32])[CH2:28][C:29]([OH:31])=[O:30]>>[F:26][C:27]([F:33])([F:32])[CH2:28][C:29]([O:31][C:4]1([N:7]=[O:8])[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1)=[O:30]

Participants

4

Reactant 3

HCID 27779723,3,3-Trifluoropropionic acidHCID 12298558N-(oxan-4-ylidene)hydroxylamineHCID 178418268HCID 178418268, compound

Product 1

HCID 579544924-Nitrosotetrahydro-2H-pyran-4-yl 3,3,3-trifluoropropanoate

Procedure

4-Nitrosotetrahydro-2H-pyran-4-yl 3,3,3-trifluoropropanoate was prepared from tetrahydro-pyran-4-one oxime, lead tetraacetate and 3,3,3-trifluoropropionic acid using conditions of General Method 3. 1H NMR (360 MHz, chloroform-d) δ 3.94-4.17 (2H, m), 3.54-3.79 (2H, m), 3.37 (2H, q), 2.23-2.43 (2H, m), 1.65-1.96 (2H, m).

Sources & evidence

ORD record
ord-3acdb54d53544c91af5016f889d7c4dd
Source dataset
uspto-grants-2012_11
Patent number
US08318705B2

Reaction notes

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