Acetic Acid → HCID 178517820, compound

Participants

Reaction Steps

A mixture of 334 mg (1.33 mmol) 2,4,7-Trichloro-6-fluoro-quinazoline (WO9532205) and 6.6 mL 1N NaOH aq. in 2 mL THF was stirred for 2 h at room temperature. The pH of the mixture was adjusted to pH=4-5 with acetic acid. The precipitate was filtered of to yield the title compound which was used in the consecutive step without further purification.

Provenance & Evidence