Acetic Acid → HCID 178517820, compound

HRID 1879921Notes

Reaction equation

HRID 1879921 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][C:6]([Cl:14])=[C:7]([F:13])[CH:8]=2)[N:3]=1.[OH-].[Na+].C(O)(=[O:19])C>C1COCC1>[Cl:1][C:2]1[N:11]=[C:10]([OH:19])[C:9]2[C:4](=[CH:5][C:6]([Cl:14])=[C:7]([F:13])[CH:8]=2)[N:3]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 214740052,4,7-Trichloro-6-fluoroquinazoline

Product 1

HCID 178517820HCID 178517820, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 334 mg (1.33 mmol) 2,4,7-Trichloro-6-fluoro-quinazoline (WO9532205) and 6.6 mL 1N NaOH aq. in 2 mL THF was stirred for 2 h at room temperature. The pH of the mixture was adjusted to pH=4-5 with acetic acid. The precipitate was filtered of to yield the title compound which was used in the consecutive step without further purification.

Workup

  1. filtrationThe precipitate was filtered of

Sources & evidence

ORD record
ord-d064d6a2b8734edab4d48ab2923cfc27
Source dataset
uspto-grants-2012_11
Patent number
US08318749B2

Reaction notes

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