1-Methylpiperazine → HCID 11467129, compound

HRID 1879954Notes

Reaction equation

HRID 1879954 reaction equation
Cl.Cl.[Cl:3][C:4]1[C:5]([F:35])=[C:6]([CH:31]=[CH:32][C:33]=1[F:34])[NH:7][C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:29][CH3:30])=[C:15]([O:18][CH:19]3[CH2:24][CH2:23][N:22]([CH2:25][C:26]([OH:28])=O)[CH2:21][CH2:20]3)[CH:16]=2)[N:11]=[CH:10][N:9]=1.[CH3:36][N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1>>[Cl:3][C:4]1[C:5]([F:35])=[C:6]([CH:31]=[CH:32][C:33]=1[F:34])[NH:7][C:8]1[C:17]2[C:12](=[CH:13][C:14]([O:29][CH3:30])=[C:15]([O:18][CH:19]3[CH2:24][CH2:23][N:22]([CH2:25][C:26]([N:40]4[CH2:41][CH2:42][N:37]([CH3:36])[CH2:38][CH2:39]4)=[O:28])[CH2:21][CH2:20]3)[CH:16]=2)[N:11]=[CH:10][N:9]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 69225921HCID 69225921, compound

Product 1

HCID 11467129HCID 11467129, compoundYield 56%

Procedure

[4-({4-(3-chloro-2,4-difluoroanilino)-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]acetic acid dihydrochloride salt and N-methylpiperazine were converted to the title compound (126 mg, 56%) using the procedure according to Examples 6 to 10.

Sources & evidence

ORD record
ord-8acbc89dc3c74348ac772ff0d91ad346
Source dataset
uspto-grants-2012_11
Patent number
US08318752B2

Reaction notes

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