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HRID1880024

反应详情

EQUATION

反应方程式

HRID 1880024 的结构方程式

REACTANTS

反应物

2
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：Cn1c(C(=O)c2ccc(Oc3ncccc3C#C[Si](C)(C)C)cc2)nc2ccccc21
HCID59327100

未命名化合物

PRODUCTS

生成物

1
结构：C#Cc1cccnc1Oc1ccc(C(=O)c2nc3ccccc3n2C)cc1
HCID59327156

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

(1-M ethyl-1H-benzo[d]imidazol-2-yl)(4-(3-(2-(trimethylsilyl)ethynyl)pyridin-2-yloxy)phenyl)methanone (0.19 g, 0.44 mmol) and potassium carbonate (0.12 g, 0.88 mmol) was suspended in 1 mL MeOH. The mixture was stirred for 2 h at RT. Purification by prep-plate TLC (10% MeOH/DCM) afforded (4-(3-ethynylpyridin-2-yloxy)phenyl)(1-methyl-1H-benzo[d]imidazol-2-yl)methanone. MS (ESI, pos. ion) m/z: 354.0 (M+1). IC50 (uM) +++.

WORKUP

后处理

  1. customPurification by prep-plate TLC (10% MeOH/DCM)