HCID 57606688, compound → 2-Fluoro-3-(1,4-dioxaspiro[4.5]decan-8-yl)pyridine

HRID 1880107Notes

Reaction equation

HRID 1880107 reaction equation
[F:1][C:2]1[C:7]([C:8]2[CH2:17][CH2:16][C:11]3([O:15][CH2:14][CH2:13][O:12]3)[CH2:10][CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[H][H]>C1COCC1.[Pd]>[F:1][C:2]1[C:7]([CH:8]2[CH2:17][CH2:16][C:11]3([O:15][CH2:14][CH2:13][O:12]3)[CH2:10][CH2:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 2

HCID 57606688HCID 57606688, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 593272352-Fluoro-3-(1,4-dioxaspiro[4.5]decan-8-yl)pyridine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
40 °C

Procedure

To a solution of 2-fluoro-3-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)pyridine (7.99 g, 34.0 mmol) in THF (40 mL) under argon atmosphere was added palladium on carbon (10% activated, 0.80 g). The mixture was placed under 1 atmosphere of hydrogen and stirred for 5 h at 40° C. After placing the mixture back under argon atmosphere, the mixture was filtered through celite and the filtrate was concentrated in vacuo to give 2-fluoro-3-(1,4-dioxaspiro[4.5]decan-8-yl)pyridine. MS (ESI, pos. ion) m/z: 238.1 (M+1).

Workup

  1. filtrationthe mixture was filtered through celite
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-b6b6f866a1254cbd88f529853459041d
Source dataset
uspto-grants-2012_11
Patent number
US08318718B2

Reaction notes

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