反应详情

To a solution of isopropylhydrazine hydrochloride (2.0 g, 18 mmol) in water (100 mL) was added acetic acid (1.7 mL) followed by the dropwise addition of pyruvaldehyde (2.6 g, 14.5 mmol) in water. The solution was stirred at room temperature overnight. The aqueous layer was extracted with CH2Cl2 (4×) and the combined organic extracts were washed with sat. aq. NaHCO3. The organic extract was dried over Na2SO4, filtered and concentrated to afford 2-oxopropanal isopropylhydrazone (1.3 g, 56%).

1. extractionThe aqueous layer was extracted with CH2Cl2 (4×)
2. washthe combined organic extracts were washed with sat. aq. NaHCO3
3. extractionThe organic extract
4. dry with materialwas dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated