Glyoxal → HCID 66920583, compound

Participants

Reaction Steps

A 40% aqueous solution of glyoxal (1.88 mL, 16.4 mmol) was added to 2-oxopropanal cyclopentylhydrazone (2.53 g, 16.4 mmol) in H2O (125 mL). The mixture was then heated at reflux. After 1 hour, the mixture was cooled to room temperature and extracted with CH2Cl2 (4×). The combined organic extracts were dried (Na2SO4) and concentrated under reduced pressure to afford 1.68 g (53%) of 1-(4-hydroxy-1-cyclopentyl-1H-pyrazol-3-yl)ethanone as a yellow oil. The crude product was then used in the next step without further purification.

Provenance & Evidence