反应详情

Ethyl 7-(acetyloxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-5-carboxylate (6 g, 0.018 mol) was dissolved in EtOH (100 mL) and K2CO3 (7 g, 0.05 mol) was added. The reaction mixture was heated at reflux over a period of 6 hours and evaporated. The residue was treated with water (150 mL), and the product was extracted with EtOAc (3×50 mL). The combined extracts were evaporated and the residue was purified by chromatography (EtOAc/hexane, 1:4) to afford ethyl 7-hydroxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-5-carboxylate (4 g, 85%).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux over a period of 6 hours
3. customevaporated
4. additionThe residue was treated with water (150 mL)
5. extractionthe product was extracted with EtOAc (3×50 mL)
6. customThe combined extracts were evaporated
7. customthe residue was purified by chromatography (EtOAc/hexane, 1:4)