反应详情

A solution of 1H-indazole-5-carboxylic acid methyl ester (8 g, 42.1 mmol), LiOH (5.05 g, 211 mmol), in methanol (100 mL) and water (35 mL) was stirred at room temperature for 20 hours. At the end of this time the reaction mixture was concentrated, the aqueous residue was acidified (pH˜6) using 10% aqueous citric acid (150 mL) and filtered the solid to obtain the crude product, which was washed with water (3×30 ml) and dried well to give the title compound (7 g, 95%) as a pale brown solid. 1H NMR (CDCl3): δ 8.5 (s, 1H), 8.0-8.1 (d, 1H), 7.45-7.55 (d, 1H), 2.5-2.66 (s, 3H),

1. concentrationAt the end of this time the reaction mixture was concentrated
2. filtrationfiltered the solid
3. customto obtain the crude product, which
4. washwas washed with water (3×30 ml)
5. customdried well