Lithium Hydroxide → HCID 58123089, compound

HRID 1880388Notes

Reaction equation

HRID 1880388 reaction equation
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([CH3:15])=[CH:6][C:7]([C:11]([O:13]C)=[O:12])=[CH:8]2)=[N:3]1.[Li+].[OH-]>CO.O>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([CH3:15])=[CH:6][C:7]([C:11]([OH:13])=[O:12])=[CH:8]2)=[N:3]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 66920473HCID 66920473, compound

Product 1

HCID 58123089HCID 58123089, compoundYield 107%

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Conditions

Temperature
50 °C

Procedure

To a solution of methyl 2,7-dimethyl-2H-indazole-5-carboxylate (140 mg, 0.69 mmol) in methanol/water (V:V 1:1, 2 mL) was added LiOH (38 mg, 1.6 mmol). The solution was heated at 50° C. for 1 hour, cooled to room temperature, concentrated and acidified to pH 2 with KHSO4. The solid material was isolated by filtration to provide the title compound as a white solid (140 mg, 107%).

Workup

  1. temperaturecooled to room temperature
  2. concentrationconcentrated
  3. customThe solid material was isolated by filtration

Sources & evidence

ORD record
ord-dc39c61ab1cb48178b955c36ca1d119c
Source dataset
uspto-grants-2012_11
Patent number
US08318762B2

Reaction notes

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