Lithium Hydroxide → HCID 178436698, compound

Participants

Reaction Steps

To a solution of methyl 7-ethyl-3-methyl-1H-indazole-5-carboxylic acid (240 mg, 1.10 mmol) in EtOH (13 mL) was added 1 M LiOH (2.2 mL). The mixture was heated overnight at reflux and cooled to room temperature. The solvents were removed under reduced pressure and the resultant material was suspended in 1 N HCl. The solids were isolated by vacuum filtration, washed with water, dried at 45° C. under vacuum to afford the title compound (154 mg, 69%) containing ˜10% of des-methyl material.

Provenance & Evidence